Novel Laser based technique for Tissue

Novel Laser based technique for Tissue dissectionfor hard tissue and implants histopathological evaluation:

At Patho-Logica, we pride ourselves on redefining standards in tissue and material analysis. With our novel Tissue Surgeon method, we’re setting a new benchmark in precision, efficiency, and reliability for researchers and clinicians worldwide for hard tissues and implant histopathology. This state-of-the-art tool represents a giant leap forward in laser-based preparation of biological tissues and materials, transforming how we approach the challenges of histopathological analysis and implant dissection.

 

The Need for Advanced Tissue Preparation
Histological analysis, particularly involving calcified tissues and implanted medical devices, has long been plagued by limitations of traditional methods such as hard tissue decalcification for microtomy and ground sectioning. These approaches introduce artefacts, compromise tissue-implant interfaces, and demand labor-intensive, time-consuming processes and above all a relatively poor quality of the histological image on a high power field with a marked reduction in the histological relevant data.
The Tissue Surgeon addresses these weak points head-on, delivering unparalleled precision with minimal material loss and artefact-free sectioning. By leveraging laser microtomy, our technology eliminates the constraints of conventional methods, enabling seamless preparation of high quality, delicate sections from both hard tissues and a broad range of implants.

 

Key Features of the Tissue Surgeon

  1. Contact-Free Cutting: Utilizing advanced laser microtomy, the Tissue Surgeon ensures minimal distortion by avoiding physical contact during the cutting process. This feature is crucial for preserving the integrity of tissue-implant interfaces, which are critical for accurate analysis.
  2. Ultra-Thin Sections: Produce high-quality slides with section thickness ranging from 8 to 15 microns, also suitable for diverse applications from digital morphometry  evaluation to immunohistochemistry (IHC) stain capabilities.
  3. Versatility in Applications: Perfect for various fields, including bone pathology, cardiac stents, dental implants, orthopedic devices, regenerative medicine, and preclinical studies. Whether you’re studying small animal models or large implants, the Tissue Surgeon is designed to meet your needs.
  4. Enhanced Quality Control: Optical Coherence Tomography (OCT) integration ensures real-time quality checks during sectioning, guaranteeing consistent results with every sample.
  5. Time and Resource Efficiency: The fast and straightforward operation minimizes preparation time while reducing material waste, allowing researchers to focus on analysis and discovery.

 

Unmatched Applications and Benefits

Originally designed for bone histology, the Tissue Surgeon’s capabilities have been extended to address the challenges of modern medical device research:

  • Bone and Hard Tissue Analysis: Avoid the need for decalcification,
  • maintaining tissue integrity and enabling detailed morphometric evaluations.
  • Medical Device Research: Analyze implanted devices within tissues, from cardiac stents to orthopedic screws, while preserving their interaction with surrounding biological structures.
  • Regenerative Medicine and Tissue Engineering: Support the development of advanced biomaterials, scaffolds, and implants with unparalleled precision.

 

*Rat knee, H&E, Lower left

 

Transform Your Research with Patho-Logica

The Tissue Surgeon is more than a tool; it’s a game-changer for professionals seeking accuracy, efficiency, and innovation in tissue and implant research. By integrating this revolutionary device into your workflow, you’ll elevate your capabilities, streamline your processes, and unlock new possibilities in histopathological analysis.

Ready to join the revolution? Explore the full potential of the Tissue Surgeon and discover how Patho-Logica is shaping the future of tissue analysis. Visit our website at patho-logica.com/tissue-surgeon or contact us for a personalized demonstration.

 

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