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Advanced Laser-Based technology for the preparation of biological tissues and materials in plastic embedded sections Methodological Aspects of an Advanced Technology purchased by Patho-Logica (supported by the Israeli Innovation Authority). Dr. Emmanuel Loeb   Case report: Objective: To evaluate histopathological changes in goat blood vessels following Implant + Filler implantation,...

At Patho-Logica, we are unwaveringly dedicated to quality assurance and customer satisfaction. We do so with in the following ways: GLP-OECD Certification for Histopathology and Toxicological Pathology Patho-Logica has earned the prestigious Certification in Good Laboratory Practices (GLP-OECD) for Histopathology and Toxicological Pathology from the Israel Laboratory Accreditation Authority (ISRAC),...

ISO 10993: Ensuring biological safety of medical devices in the context of the histopathological tissue evaluation. Patho-Logica is committed to the ISO 10993-6 being a global center for histopathology for invasive medical device in pre-clinical trials. We have a vast experience in the evaluation of the medical device safety within...

Methodological Aspects of Advanced Laser Microtomy for plastic embedded tissue and materials   Dr. Emmanuel Loeb Introduction Plastic embedding was originally designed for bone histology, to avoid the decalcification process and later it was adjusted to solid, and implanted medical device research: Perfect method for rigid devices. Suitable for morphometric...

Bungaro-toxin marker for histology: A powerful tool for the quantification and evaluation of the Acetyl-Choline receptors on the NMJ. Dr. Emmanuel Loeb Introduction: The neuromuscular junction (NMJ) involves a complex structure whose function is to convey action potentials from the motorneuron (MN) to skeletal muscle, resulting in stimulated contraction of...

Webinar December 2020 A professional Webinar on the topic: From a Conceptual “Idea” to a Marketed Product: Toxicology/Safety Assessment Pathology Regulatory Registration Webinar Video We discussed about: Introduction by Dr. Emmanuel Loeb, CEO, Patho-Logica, Inc. Definition and role of the various inter-related disciplines Safety assessment history (leading to the GLPs,...

CNS models in rodents: What can you expect from your experimental pathologist? Dr. Emmanuel Loeb Introduction Three major parameters are important for accurate histopathological results in CNS models: Tissue preparation for representative lesion exposure and analysis. Choice of histological tools for measuring your desired end points. Accuracy of the analytical...

Calibration of IHC for Covid-19 virus in Golden Syrian Hamsters Dr. Emmanuel loeb, Dr. Zohar Gavish, Patho-Logica Ltd. Results: The objective was to detect a specific IHC signal in relevant structures of the lung in paraffin sections (4 microns thick). Two animal groups were examined: covid-19 intranasal infected hamsters and...

How Artificial Intelligence (AI) and Deep Learning (DL) processes are shaping and influencing the work of the experimental pathologist.   Introduction Technology developments have changed and will continue to change many fields. When it comes to science and precise data, technology developments are becoming a real challenge for professionals such...

Photobiomodulation Triple Treatment in Peripheral Nerve Injury: Nerve and Muscle Response Mira M. Mandelbaum-Livnat, PhD,1 Mara Almog, PhD,1 Moshe Nissan, PhD,1 Emmanuel Loeb, DVM,2 Yuval Shapira, MD,1 and Shimon Rochkind, MD, PhD1 Abstract Background: Muscle preservation or decrease in muscle degeneration and progressive atrophy are major challenges in patients with...

A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses Vered Behar, Hadas Pahima, Adi Kozminsky-Atias, Nir Arbel, Emmanuel Loeb, Max Herzberg and Oren M. Becker Overexpression of hexokinase 2, and its binding to VDAC1 on the outer mitochondrial membrane of cancer cells, is key to their metabolic reprogramming to...

The pros and cons of animal experiments; an essay on ethical issues Author: Emmanuel Loeb As an experimental pathologist, I deal on a daily basis with tissue samples that were harvested during a controlled animal experiment, performed as part of the development process of new drugs and devices. In my...

The Usage of Animal Models for Pre-Clinical Trials: a pathological, comparative approach Author: Emmanuel Loeb. The utilazation of animal models offers the scientist a great opportunity to examine his developed product (drug or medical device) on a whole body system prior to the human trials. The animal model intends to...

Technocratic Scientific Empire – the good, the bad, and the man that could not dream Author: Emmanuel Loeb We all live in a technocratic capitalistic world that demands innovation and advanced developments to improve health and quality of life, as well as to increase income and prosperity. If we compare...

Utilizing Patients-Derived Xenografts and Histological Assessment for Personized Medicine in Oncology Author: Emmanuel Loeb Globally, 8.2 million people die each year from cancer, an estimated 13% of all deaths worldwide. There is a 70% increase in the expected new cases of cancer over the next 2 decades. According to the...

Digital morphometry quantification of dopamine activity in a 6-hydroxydopamine (6-OHDA) Parkinson model in mice Loeb E¹, Zuckerman A¹, Margalit R², Orgad U³. ¹Patho-Logica, Golda Meir Str 7, Scientific Park, Ness-Ziona, Israel. ²Science In Action, Sapir Str. 5, Scientific park, Ness-Ziona, Israel. ³Hebrew University, Koret School for veterinary medicine, Rehovot, Israel...

Use of a digital morphometry tool for histological assessment in an Elastase-induced COPD model in mice Loeb E¹, Zuckerman A¹, Margalit R², Alagem N ³, Sagiv Y ³. ¹Patho-Logica, Golda Meir Street 7, Scientific Park, Ness-Ziona, Israel. ²Science In Action, Sapir Street 5, Scientific park, Ness-Ziona, Israel. ³ Kamada Ltd,...

Comparison of methods to evaluate cuprizone-induced demyelination in mice Litinetsky La; Belinson, Ha; Geva, Ma; Blumenfeld – Katzir, Tb; Loeb, Ec; Amit- Romach, Ea; Orbach, Aa. aDiscovery & Product Development, Global Research & Development, Teva Pharmaceutical Industries Ltd., Netanya, Israel; b ImagingQ, Ramat Gan, Israel. c Patho – Logica Ltd.,...